1. Multivalent, Soluble Nano-Self Peptides Increase Phagocytosis of Antibody-Opsonized Targets while Suppressing “Self” Signaling

    Jalil, AbdelAziz R.; Hayes, Brandon H.; Andrechak, Jason C.; Xia, Yuntao; Chenoweth, David M.; Discher, Dennis E.
    ACS Nano 2020, xx, In Press. DOI: 10.1021/acsnano.0c05091

  2. Tension promotes kinetochore-microtubule release in response to Aurora B activity

    Chen, Geng-Yuan; Renda, Fioranna; Zhang, Huaiying; Gokden, Alper; Wu, Daniel Z.; Chenoweth, David M.; Khodjakov, Alexey; Lampson, Michael
    bioRxiv 2020. DOI: 10.1101/2020.06.01.127795

  3. A Rapid Synthesis of Nuclear Staining Small Fluorescent Molecules for Brain Imaging

    Suh, Sung-Eun; Jun, Joomyung V.; Hernandez, Elen; Tran, Mai N.; Betley, J. Nicholas; Chenoweth, David M.
    Cell Reports Physical Science 2020, 1(10), Accepted. DOI: 10.1016/j.xcrp.2020.100227


    Selected for a Journal Cover

  4. Rational Design of Small Molecule Fluorescent Probes for Biological Applications

    Jun, Joomyung V.; Chenoweth, David M.; Petersson, E. James
    Organic & Biomolecular Chemistry 2020, 18, 5747-5763. DOI: 10.1039/D0OB01131B



  5. Rules for the Design of Aza-Glycine Stabilized Triple-Helical Collagen Peptides

    Melton, Samuel D.; Brackhahn, Emily A.E.; Orlin, Samuel J.; Jin, Pengfei; Chenoweth, David M.
    Chemical Science 2020, 11, 10638-10646. DOI: 10.1039/D0SC03003A


    Selected for a Journal Cover

  6. Photoaffinity Evaluation of RNA Ligation-Sequencing (PEARL-Seq): A Platform for the Analysis of Small Molecule-RNA Interactions

    Mukherjee, Herschel; Blain, J. Craig; Vandivier, Lee; Chin, Donovan; Friedman, Jessica E.; Liu, Fei; Maillet, Ashley; Fang, Chao; Kaplan, Jenifer; Li, Jinxing; Chenoweth, David M.; Christensen, Allan B.; Petersen, Lars K.; Vest Hansen, Nils J.; Barrera, Luis; Seiler, Michael; Kubica, Neil; Kumaravel, Gnanasambandam; Petter, Jennifer
    ACS Chemical Biology 2020, #, In Press. DOI: 10.1021/acschembio.0c00357



  7. Nuclear body phase separation drives telomere clustering in ALT cancer cells

    Zhang, Huaiying; Zhao, Rongwei; Tones, Jason; Liu, Michel; Dilley, Robert; Chenoweth, David M.; Greenberg, Roger A.; Lampson, Michael
    Molecular Biology of the Cell 2020, mbc, E19-10-0589. DOI: 10.1091/mbc.E19-10-0589



  8. Photoconvertible Diazaxanthilidene Dyes for Live Cell Imaging

    Lackner, Rachel M.; Johnny, Christopher L.; Chenoweth, David M.
    Methods in Enzymology 2020, 639, 379-388. DOI: 10.1016/bs.mie.2020.04.024



  9. Photoactivatable Trimethoprim-Based Probes for Spatiotemporal Control of Biological Processes

    Wu, Daniel Z.; Lampson, Michael A.; Chenoweth, David M.
    Methods in Enzymology 2020, 638, 273-294. DOI: 10.1016/bs.mie.2020.03.015



  10. Quinoline-Based Fluorescent Small Molecules for Live Cell Imaging

    Lackner, Rachel M.; Jun, Joomyung V.; Petersson, James P.; Chenoweth, David M.
    Methods in Enzymology 2020, 640, 309-326. DOI: 10.1016/bs.mie.2020.04.060



  11. Halogen Bonding Facilitates Intersystem Crossing in Iodo-BODIPY Chromophores

    Lee, Yumin; Malamakal, Roy M.; Chenoweth, David M.; Anna, Jessica M.
    J. Phys. Chem. Lett. 2020, 11, 877-884. DOI: 10.1021/acs.jpclett.9b03753



  12. Incorporation of Aza-Glycine into Collagen Peptides

    Melton, Samuel D.; Smith, Mason S.; Chenoweth, David M.
    J. Org. Chem. 2019, 85, 1706-1711. DOI: 10.1021/acs.joc.9b02539


    Invited Contribution: Modern Peptide and Protein Chemistry

  13. Sterics and Stereoelectronics in Aza-Glycine: Impact of Aza-Glycine Preorganization in Triple Helical Collagen

    Harris, Trevor; Chenoweth, David M.
    J. Am. Chem. Soc. 2019, 141, 18021-18029. DOI: 10.1021/jacs.9b05524



  14. Aza-Proline Effectively Mimics L-Proline Stereochemistry in Triple Helical Collagen

    Kasznel, Alexander; Harris, Trevor; Porter, Nicholas; Zhang, Yitao; Chenoweth, David M.
    Chemical Science 2019, 10, 6979-6983. DOI: 10.1039/C9SC02211B



  15. Reversible optogenetic control of protein function and localization

    Wu, Daniel Z.; Lackner, Rachel M.; Aonbangkhen, Chanat; Lampson, Michael A.; Chenoweth, David M.
    Methods in Enzymology 2019, 624, 25-45. DOI: 10.1016/bs.mie.2019.05.002



  16. A “Clickable” Photoconvertible Small Fluorescent Molecule as a Minimalist Probe for Tracking Individual Biomolecule Complexes

    Jun, Joomyung V.; Haney, Conor M.; Karpowicz Jr., Richard J.; Giannakoulias, Sam; Lee, Virginia M.-Y.; Petersson, E. James; Chenoweth, David M.
    J. Am. Chem. Soc. 2019, 141, 1893-1897. DOI: 10.1021/jacs.8b13094



  17. Variation in the Yaa Position of Collagen Peptides Containing AzaGlycine

    Melton, Samuel D.; Chenoweth, David M.
    ChemComm 2018, 54, 11937-11940. DOI: 10.1039/c8cc06372a


    Invited Contribution: Emerging Investigators Special Issue 2018

  18. Reversible Control of Protein Localization in Living Cells using a Photocaged-Photocleavable Chemical Dimerizer

    Aonbangkhen, Chanat; Zhang, Huaiying; Wu, Daniel Z.; Lampson, Michael A.; Chenoweth, David M.
    J. Am. Chem. Soc. 2018, 140, 11926-11930. DOI: 10.1021/jacs.8b07753



  19. The mechanism of the triple aryne–tetrazine reaction cascade: theory and experiment

    Suh, Sung-Eun; Chen, Shuming; Houk, K. N.; Chenoweth, David M.
    Chemical Science 2018, 9, 7688-7693. DOI: 10.1039/C8SC01796D



  20. Rational Design and Facile Synthesis of a Highly Tunable Quinoline-Based Fluorescent Small-Molecule Scaffold for Live Cell Imaging

    Jun, Joomyung V.; Petersson, E. James; Chenoweth, David M.
    J. Am. Chem. Soc. 2018, 140, 9486-9493. DOI: 10.1021/jacs.8b03738



  21. Optogenetic control of mitosis with photocaged chemical dimerizers

    Zhang, Huaiying; Chenoweth, David M.; Lampson, Michael A.
    Methods in Cell Biology 2018, 144, 157-164. DOI: 10.1016/bs.mcb.2018.03.006



  22. Optogenetic manipulation of mouse oocytes

    Akera, Takashi; Chenoweth, David M.; Lampson, Michael A.
    Methods in Molecular Biology 2018, 1818, 129-135. DOI: 10.1007/978-1-4939-8603-3_13



  23. Protein Kinase R-Like Endoplasmic Reticulum Kinase is a mediator of stretch in ventilator-induced lung injury

    Dolinay, Tamas; Aonbangkhen, Chanat; Zacharias, William; Cantu, Edward; Pogoriler, Jennifer; Stablow, Alec; Lawrence, Gladys G.; Suzuki, Yoshikazu; Chenoweth, David M.; Morrisey, Edward; Christie, Jason D.; Beers, Michael F.; Margulies, Susan S.
    Respiratory Research 2018, 19:157, 1-14. DOI: 10.1186/s12931-018-0856-2



  24. Optochemical Control of Protein Localization and Activity within Cell-like Compartments

    Caldwell, Reese M.; Bermudez, Jessica G.; Thai, David; Aonbangkhen, Chanat; Schuster, Benjamin S.; Courtney, Taylor; Deiters, Alexander; Hammer, Daniel A.; Chenoweth, David M.; Good, Matthew C.
    Biochemistry 2018, 57, 2590-2596. DOI: 10.1021/acs.biochem.8b00131



  25. Improving the fluorescent probe acridonylalanine through a combination of theory and experiment

    Sungwienwong, Itthipol; Ferrie, John J.; Jun, Joomyung V.; Liu, Chunxiao; Taylor M. Barrett, Zachary M. Hostetler, Naoya Ieda, Amara Hendricks, Muthusamy, Anand K.; Kohli, Rahul M.; Chenoweth, David M.; Petersson, George A.; Petersson, E. James
    J. Phys. Org. Chem. 2018, 31, e3813. DOI: 10.1002/poc.3813



  26. Spindle asymmetry drives non-mendelian chromosome segregation

    Akera, Takashi; Chmatal, Lukas; Trimm, Emily; Yang, Karren; Aonbangkhen, Chanat; Chenoweth, David M.; Janke, Carsten; Schultz, Richard M.; Lampson, Michael A.
    Science 2017, 358, 6363, 668-672. DOI: 10.1126/science.aan0092



    27. See Science Perspective by Francis J. McNally Here:
    Competing chromosomes explain junk DNA
    Science 2017, 358, 6363, 594-595.Competing chromosomes explain junk DNA
    See Penn News Article Here:
    Penn Biologists Show How Chromosomes ‘Cheat’ for the Chance to Get Into an Egg.How chromosomes cheat

  27. Ultrafast Solvation Dynamics and Vibrational Coherences of Halogenated Boron-Dipyrromethene Derivatives Revealed Through Two-Dimensional Electronic Spectroscopy

    Lee, Yumin; Das, Saptaparna; Malamakal, Roy M.; Meloni, Stephen; Chenoweth, David M.; Anna, Jessica M.
    J. Am. Chem. Soc. 2017, 139, 14733-14742. DOI: 10.1021/jacs.7b08558



  28. Structural Basis for Aza-Glycine Stabilization of Collagen

    Kasznel, Alexander J.; Zhang, Yitao; Hai, Yang; Chenoweth, David M.
    J. Am. Chem. Soc. 2017, 139, 9427-9430. DOI: 10.1021/jacs.7b03398



  29. Optogenetic Tools for Controlling Kinetochore Function in Live Cells

    Zhang, Huaiying; Aonbangkhen, Chanat; Tarasovetc, Ekaterina; Ballister, Edward R.; Chenoweth*, David M.; Lampson*, Michael A.
    Nature Chemical Biology 2017, 13, 1096-1101. (*Shared corresponding authors) DOI: 10.1038/nchembio.2456



    30. See Nature Chemical Biology News & Views Story by Figueiredo & Maiato here:
    Kinetochore Regulation: Let there be light
    Nature Chemical Biology 2017, 13, 1058-1059.
    See Highlight in Nature Methods here:

    Cell biology: Optimized light-dependent dimerization
    Nature Methods 2017, 14, 944.

  30. The Effects of Thioamide Backbone Substitution on Protein Stability: A study in α-helical, β-sheet, and polyproline II helical contexts

    Walters, Christopher; Szantai-Kis, Daniel; Zhang, Yitao; Reinert, Zachary; Horne, W. Seth; Chenoweth, David M.; Petersson, E. James
    Chemical Science 2017, 8, 2868-2877. DOI: 10.1039/c6sc05580j



  31. Shape Changing Thin Films Powered by DNA Hybridization

    Shim, Tae Soup; Estephan, Zaki G.; Qian, Zhaoxia; Prosser, Jacob H.; Lee, Su Yeon; Chenoweth, David M.; Lee, Daeyeon; Park, So-Jung; Crocker, John C.
    Nature Nanotechnology 2017, 12, 41-47. DOI: 10.1038/nnano.2016.192



  32. Aryne Compatible Solvents are not Always Innocent

    Suh, Sung-Eun; Chenoweth, David M.
    Organic Letters 2016, 18, 4080-4083. DOI: 10.1021/acs.orglett.6b01977



  33. DNA Island Formation on Binary Block Copolymer Vesicles

    Luo, Qingjie; Shi, Zheng; Zhang, Yitao; Chen, Xi-Jun; Baumgart, Tobias; Chenoweth, David M.; Park, So-Jung
    J. Am. Chem. Soc. 2016, 138, 10157-10162. DOI: 10.1021/jacs.6b04076



  34. A General Solution for Stabilizing Triple Helical Collagen

    Zhang, Yitao; Herling, Madison; Chenoweth, David M.
    J. Am. Chem. Soc. 2016, 138, 9751-9754. DOI: 10.1021/jacs.6b03823



  35. Modulation of the E. coli rpoH Temperature Sensor Using Triptycene-Based Small Molecules

    Barros, Stephanie A.; Yoon, Ina; Chenoweth, David M.
    Angew. Chem. Int. Ed. 2016, 55, 8258-8261. DOI: 10.1002/anie.201601626/anie



  36. Electronic interactions of i, i + 1 dithioamides: increased fluorescence quenching and evidence for n-to-pi* interactions

    Huang, Yun; Ferrie, John J.; Chen, Xing; Zhang, Yitao; Szantai-Kis, D. Miklos; Chenoweth, David M.; Petersson, E. James
    Chem. Comm. 2016, 52, 7798-7801. DOI: 10.1039/c6cc00105j



  37. Bridgehead-substituted Triptycenes for Discovery of Nucleic Acid Junction Binders

    Barros, Stephanie A.; Yoon, Ina; Suh, Sung-Eun; Chenoweth, David M.
    Organic Letters 2016, 18, 2423-2426. DOI: 10.1021/acs.orglett.6b00945



  38. Synthesis of 9-Substituted Triptycene Building Blocks for Solid-Phase Diversification and Nucleic Acid Junction Targeting

    Yoon*, Ina; Suh*, Sung-Eun; Barros, Stephanie A.; Chenoweth, David M.
    Organic Letters 2016, 18, 1096-1099. (*Equally Contributing Authors) DOI: 10.1021/acs.orglett.6b00169



  39. Aza-Glycine Induces Collagen Hyperstability

    Zhang, Yitao; Malamakal, Roy M.; Chenoweth, David M.
    J. Am. Chem. Soc. 2015, 137, 12422-12425. DOI: 10.1021/jacs.5b04590



  40. A Single Stereodynamic Center Modulates the Rate of Self-Assembly in a Biomolecular System

    Zhang, Yitao; Malamakal, Roy M.; Chenoweth, David M.
    Angew. Chem. Int. Ed. 2015, 54, 10826-10832. DOI: 10.1002/anie.201504459



  41. Triple Aryne–Tetrazine Reaction Enabling Rapid Access to a New Class of Polyaromatic Heterocycles

    Suh, Sung-Eun; Barros, Stephanie A.; Chenoweth, David M.
    Chemical Science 2015, 6, 5128-5132. DOI: 10.1039/c5sc01726b



  42. Synthesis and Properties of Lysosome-Specific Photoactivatable Probes for Live-Cell Imaging

    Tran, Mai N.; Chenoweth, David M.
    Chemical Science 2015, 6, 4508-4512. DOI: 10.1039/c5sc01601k



  43. Triptycene-Based Small Molecules Modulate (CAG)·(CTG) Repeat Junctions

    Barros, Stephanie A.; Chenoweth, David M.
    Chemical Science 2015, 6, 4752-4755. DOI: 10.1039/c5sc01595b



  44. Photoelectrocyclization as an Activation Mechanism for Organelle Specific Live-Cell Imaging Probes

    Tran, Mai N.; Chenoweth, David M.
    Angew. Chem. Int. Ed. 2015, 54, 6442-6446. DOI: 10.1002/anie.201502403




  45. Optogenetic Control of Organelle Transport Using a Photocaged Chemical Inducer of Dimerization

    Ballister, Edward R.; Ayloo, Swathi; Chenoweth, David M.; Lampson, Michael A.; Holzbaur, Erika L.F.
    Current Biology 2015, 10, R407-R408. DOI: 10.1016/j.cub.2015.03.056



  46. Localized Light-Induced Protein Dimerization in Living Cells using a Photocaged Dimerizer

    Ballister, Edward R.; Aonbangkhen, Chanat; Mayo, Alyssa M.; Lampson, Michael A.; Chenoweth, David M.
    Nature Communications 2014, 5, 5475. DOI: 10.1038/ncomms6475



  47. Recognition of Nucleic Acid Junctions Using Triptycene-Based Molecules

    Barros, Stephanie A.; Chenoweth, David M.
    Angew. Chem. Int. Ed. 2014, 53, 13746-13750. DOI: 10.1002/anie.201407061


  48. Synthesis and Conformational Dynamics of the Reported Structure of Xylopyridine A

    Rarig, Robert-André F.; Tran, Mai N.; Chenoweth, David M.
    J. Am. Chem. Soc. 2013, 135, 9213-9219. DOI: 10.1021/ja404737q



  49. Pyrrole-Imidazole Polyamides Distinguish Between Double-Helical DNA and RNA

    Chenoweth, David M.; Meier, Jordan L.; Dervan, Peter B.
    Angew. Chem. Int. Ed. 2012, 52, 415-418. DOI: 10.1002/anie.201205775





Publications Prior to UPenn

  1. DNA−CNT Nanowire Networks for DNA Detection

    Weizmann, Yossi; Chenoweth, David M.; Swager, Timothy, M.
    J. Am. Chem. Soc. 2011, 133, 3238–3241 DOI: 10.1021/ja109180d



  2. Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding

    Chenoweth, David M.; Dervan, Peter B.
    J. Am. Chem. Soc. 2010, 132, 14521-14529. DOI: 10.1021/ja105068b
  3. Addressable Terminally-Linked DNA-CNT Nanowires

    Weizmann, Yossi; Chenoweth, David M.; Swager, Timothy, M.
    J. Am. Chem. Soc. 2010, 132, 14009–14011. DOI: 10.1021/ja109180d



  4. Regiospecific Synthesis of Au-Nanorod/SWCNT/Au-Nanorod Heterojunctions

    Weizmann, Yossi; Lim, Jeewoo; Chenoweth, David M.; Swager, Timothy, M.
    Nano Lett. 2010, 10, 2466–2469. DOI: 10.1021/nl1008025



  5. Cyclooctyne-based Reagents for Uncatalyzed Click Chemistry: A Computational Survey

    Chenoweth, Kimberly; Chenoweth, David M.; Goddard III, William A.
    Org. Biomol. Chem. 2009, 7, 5255–5258. DOI: 10.1039/B911482C



  6. Oligomerization Route to DNA Binding Py-Im Polyamide Macrocycles

    Chenoweth, David M.; Harki, Daniel A.; Dervan, Peter B.
    Org. Lett. 2009, 11, 3590–3593. DOI: 10.1021/ol901311m



  7. Allosteric Modulation of DNA by Small Molecules

    Chenoweth, David M.; Dervan, Peter B.
    Proc. Natl. Acad. Sci. USA 2009, 106, 13175–13179. DOI: 10.1073/pnas.0906532106



  8. Solution-Phase Synthesis of Pyrrole-Imidazole Polyamides

    Chenoweth, David M.; Harki, Daniel A.; Dervan, Peter B.
    J. Am. Chem. Soc. 2009, 131, 7175–7181. DOI: 10.1021/ja901307m



  9. Cyclic Pyrrole-Imidazole Polyamides Targeted to the Androgen Response Element

    Chenoweth, David M.; Harki, Daniel A.; Daniel A.; Phillips, John W.; Dose, Christian;Dervan, Peter B.
    J. Am. Chem. Soc. 2009, 131, 7182–7188. DOI: 10.1021/ja901309z



  10. Lancifodilactone G: Insights about an Unusually Stable Enol

    Chenoweth, David M.; Chenoweth, Kimberly; Goddard III, William A.
    J. Org. Chem. 2008, 73, 6853–6856. DOI: 10.1021/jo8012385



  11. Next Generation Hairpin Polyamides with (R)-3,4-Diaminobutyric Acid Turn Unit

    Dose, Christian; Farkas, Michelle E.; Chenoweth, David M.; Dervan, Peter B.
    J. Am. Chem. Soc. 2008, 130, 6859-6866. DOI: 10.1021/ja800888d



  12. Fluorescent Sequence-Specific dsDNA Binding Oligomers

    Chenoweth, David M.; Viger, Anne; Dervan, Peter B.
    J. Am. Chem. Soc. 2007, 129, 2216-2217. DOI: 10.1021/ja0682576



  13. Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-k B binding inhibition

    Chenoweth, David M.; Poposki, Julie A.; Marques, Michael A.; Dervan, Peter B.
    Bioorg. Med. Chem. 2007, 15, 759-770. DOI: 10.1016/j.bmc.2006.10.051



  14. Programmable Oligomers for Minor Groove DNA Recognition

    Doss, Raymond M.; Marques, Michael M.; Foister, Shane; Chenoweth, David M.; Dervan, Peter B.
    J. Am. Chem. Soc. 2006, 128, 9074-9079. DOI: 10.1021/ja0621795



  15. Selective, non-amino-acid allosteric potentiators of mGlu2 receptors

    Britton, T.; Barda, D.; Hornback, W.; Jagdmann, G.E.; Henry, S.; Fichtner, M.; Wang, Z.Q.; Coleman, D.; Chenoweth, D.; Vaught, G.; Fivush, A.; Dressman, B.; White, R.; Milot, G.; Herr, R.J.; Burry, L.; Johnson, M.; Large, T.; Monn, J.; Schoepp, D.
    Neuropharmacology 2002, 43, 279.

  16. Selective, non-amino acid allosteric mGlu2 receptor potentiators inhibit dural plasma protein extravasation; A potential role in the treatment of migraine

    Johnson, K.; Dieckman, D.; Britton, T.; Johnson, M.; Jagdmann, E.; Monn, J.; Barda, D.; Henry, S.; Chenoweth, D.; Coleman, D.; Schoepp, D.
    Neuropharmacology 2002, 43, 291.

  17. Separation using planar chromatography with electroosmotic flow

    Nurok, D.; Frost, M. C.; Chenoweth, D. M.
    J. Chromatogr. A 2000, 903, 211-217. DOI: 10.1016/S0021-9673(00)00889-X

  18. The performance of planar chromatography using electroosmotic flow

    Nurok, David; Frost, Megan C.; Pritchard, Cary L.; Chenoweth, David M.
    J. Planar Chromatogr.-Mod. TLC 1998, 11, 244-246.


Patents